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Silymarin Provide Shield in Cyclosporine A Stimulate Hepatorenal Toxicity in Rat

Author :
  • Rizwana Bilqees
  • Sahara Umar
Abstract
Silymarin, an extract from the Silybum marianum plant containing numerous flavonolignans, has gained considerable attention over the past decade as an herbal cure for hepatic treatment. Due to their hepatotoxic and nephrotoxic effects, the use of CsA is often limited as an immunosuppressive agent. The purpose of this research was to determine the silymarin's protective effect against CSA mediated hepatorenal toxicity in rats. Four classes of Wistar albino rats (number of rats (n) = 10 per group) were included in the study: standard regulation, CsA, CsA+Silymarin (S50), and CsA+Silymarin (S200). Both medications were administered regularly by oral gavage for 4 weeks and their impact was tested on serum levels of organ function markers (SGOT, SGPT, BUN, bilirubin, creatinine), oxidative stress markers (GSH, TBARS, SOD), and inflammation (PGE2, TNF‐α, nitrite, MPO). Dose-dependent administration of silymarin along with CsA has increased kidney and liver function risk. Important and equivalent increase in oxidative stress levels in the tissue, inflammation was also detected during treatment with the test medications. The findings of this research indicate that in patients undergoing long-term CsA treatment, silymarin has the capacity for medicinal use to preserve their roles for the kidney and liver functions.
Keywords : Hepatorenal toxicity, Inflammation, Oxidative Stress, Cyclosporine A, Silymarin
Volume 1 | Issue 4
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